Adverse Childhood Experiences (ACEs) are traumatic or stressful experiences, such as abuse or neglect, that occur during childhood or adolescence. ACEs can harm a child’s brain and its development, which can lead to long-term negative health and social outcomes. Armed with powerful new insights into how toxic stress changes the physiology of early brain development, we can begin to find sustainable solutions to childhood trauma by empowering student resilience. We now know that leading causes of disease and disability, learning and productivity problems have their roots in the cumulative neurodevelopmental impacts of ACEs. The ACE Interface Workshop explains why ACEs have so much effect in people’s lives, and what we can do to support widespread awareness, promote understanding, and empower educators to improve and enhance resiliency in their students.